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Aptevo Therapeutics Begins Patient Dosing in Phase 2 Clinical Trial of Otlertuzumab in Peripheral T-Cell Lymphoma

APTEVO THERAPEUTICS INC (APVO)  More Company Research Source: GlobeNewswire
US:NASDAQ Investor Relations: ir.aptevotherapeutics.com/investor-overview
PDF SEATTLE, Jan. 08, 2018 (GLOBE NEWSWIRE) -- Aptevo Therapeutics Inc. (Nasdaq:APVO), a biotechnology company focused on developing novel oncology and hematology therapeutics, today announced that it has commenced patient dosing in a Phase 2 clinical evaluation of otlertuzumab in a new indication – peripheral T-cell lymphoma (PTCL).  Otlertuzumab is a monospecific antibody targeting CD37 that was built on Aptevo’s ADAPTIR™ modular protein therapeutic platform. “Clinical proof-of-concept data from a randomized Phase 2 study demonstrated the efficacy and tolerability of otlertuzumab with bendamustine in relapsed chronic lymphocytic lymphoma (CLL).  In this study there was a significant increase in median progression free survival, from approximately 10 to 16 months in patients receiving the combination of otlertuzumab and bendamustine,” said Scott Stromatt, M.D., Senior Vice President and Chief Medical Officer for Aptevo.  “We were intrigued by recent reports in the literature showing [Read more]

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