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Alexion up 5% on difficulty in certain PNH patients switching from Soliris to Ra Pharma's RA101495 [Seeking Alpha]

RA PHARMACEUTICALS (RARX)  More Company Research Source: Seeking Alpha
Last ra pharmaceuticals earnings: 8/8 07:15 am Check Earnings Report
US:NASDAQ Investor Relations: rapharma.com/news-investors
PDF Alexion up 5% on difficulty in certain PNH patients switching from Soliris to Ra Pharma's RA101495APhase 2 clinical trial assessing Ra Pharmaceuticals' (RARX+2.4%) subcutaneously administered RA101495 in patients with paroxysmal nocturnal hemoglobinuria (PNH) showed a positive effect in patients who were naive to Alexion Therapeutics' (ALXN+5.3%) Soliris (eculizumab). The data weren't so good for patients on Soliris therapy, however.In 10 PNH patients naive to Soliris, treatment with RA101495 met the primary endpoint of a sustained reduction in lactate dehydrogenase (LDH) levels from baseline to the mean of weeks 6 - 12 (p=0.002) with near-complete suppression of complement activity. Half (n=3/6) of the transfusion-dependent subjects prior to enrollment remained transfusion-free during the study period.In patients on Soliris who switched to RA101495, five transfusion-independent patients maintained stable LDH levels with one withdrawal due to breakthrough hemolysis (return of PNH symp [Read more]

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