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Achieve Life Sciences' cytisine shows encouraging effect in smoking cessation study; shares up 54% [Seeking Alpha]

ACHIEVE LIFE SCIENCES INC (ACHV)  More Company Research Source: Seeking Alpha
US:NASDAQ Investor Relations: ir.achievelifesciences.com
PDF Achieve Life Sciences' cytisine shows encouraging effect in smoking cessation study; shares up 54%Thinly traded nano cap Achieve Life Sciences (NASDAQ:ACHV) is up54% premarket on increased volume in response to its announcement ofpositive results from a Phase 1/2 clinical trial evaluating cytisine in 24 healthy volunteer smokers over a 25-day treatment period.Pharmacokinetic data showed increases in plasma concentration between the standard and higher doses of cytisine with no evidence of drug accumulation. 58% (n=14/24) of smokers achieved abstinence on day 26, 50% (n=6/12) in the 1.5 mg arm and 67% (n=8/12) in the 3.0 mg arm. Those who were unable to quit entirely, were smoking considerably less cigarettes per day at the end of treatment.On the safety front, most adverse events (AEs) were mild and transitory. The most frequent AE was transient headache.Cytisine is a plant-based alkaloid with a strong affinity to the nicotinic acetylcholine receptor.Phase 3 development will start mid [Read more]

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