Adaptimmune Presents Preclinical Data for its Next Generation SPEAR T-cell Targeting MAGE-A4 at the American Association for Cancer Research (AACR) Annual Meeting
Adaptimmune Therapeutics plc - American Depositary Shares (ADAP)
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ir.adaptimmune.com/phoenix.zhtml?c=253991&p=irol-newsarticle&id=2255800
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Source: GlobeNewswire
PHILADELPHIA and OXFORD, United Kingdom, April 01, 2019 (GLOBE NEWSWIRE) -- Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in T-cell therapy to treat cancer, presented promising preclinical data at the annual AACR meeting from its next generation SPEAR T-cell targeting MAGE-A4. This next generation SPEAR T-cell, known as ADP-A2M4CD8, expresses the CD8a co-receptor alongside the engineered TCR that targets MAGE-A4. Co-expression of CD8a is anticipated to broaden the immune response against solid tumors and increase antitumor activity by converting CD4+ helper cells into CD8+ killer or cytotoxic T-cells. The preclinical data demonstrate that the addition of CD8a with the engineered TCR in vitro improved engagement and function in CD4+ T-cells that may support clonal expansion of CD8+ T-cells, differentiation into effector and memory T-cells, as well as engage the wider immune system in antitumor responses. “Our next generation programs are designed to enhance our existing SPEA
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ADAP
Sec Filings
- 4/12/24 - Form 8-K
- 4/11/24 - Form DEF
- 4/2/24 - Form SC
- ADAP's page on the SEC website