J&J bails on Alzheimer's candidate atabecestat on toxicity issues [Seeking Alpha]
ALLERGAN INC (AGN)
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Source: Seeking Alpha
J&J; bails on Alzheimer's candidate atabecestat on toxicity issuesJohnson & Johnson (JNJ+0.4%) unit Janssen has decided toterminate its Phase 2b/3 clinical trial,EARLY, and aPhase 2 long-term safety study evaluating BACE inhibitor atabecestat for slowing the rate of cognitive decline in patients with preclinical Alzheimer's disease (AD). The company took action after observing serious elevations in liver enzymes in certain treated patients that undermined the drug's benefit-risk profile.Janssen's decision is another setback for BACE (beta-secretase) inhibition as a treatment approach for patients at risk of developing AD.BACE is an enzyme that plays a key role in the formation of amyloid plaques in the brain, characteristic in AD sufferers.Several months ago, Merck pulled the plug on its BACE candidate verubecestat after determining its late-stage study would likely fail. Vitae Pharmaceuticals (AGN-0.6%) and collaboration partner Boehringer Ingelheim terminated their efforts on BI 118
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