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Stock impact report

Akari Therapeutics Announces Expanded Ophthalmology Program Based on Positive Emerging Data on LTB4-C5 Dual Action in Surface and Back of the Eye Diseases

Akari Therapeutics Plc - American Depositary Shares (AKTX) 
US:NASDAQ Investor Relations: investor.akaritx.com/investor-relations
Company Research Source: GlobeNewswire
In an experimental back of the eye, autoimmune uveitis (EAU) model to be reported in a poster presentation at ARVO 2019, nomacopan (Coversin) and its long acting variants administered intravitreally, reported:?  Significant improvement in clinical scoring versus control?  Co-localization of LTB4 and C5a receptors in retinal inflammatory cells seen for the first time?  Significant downregulation of pro-inflammatory T-helper 17 cells and the inflammatory cytokine IL-17?  Efficacy of  LTB4 and C5 inhibition, supporting its potential as a novel, non-steroidal therapy across a range of severe ‘back-of-eye’ diseasesIn a “first in eye” Phase I/II study in atopic keratoconjunctivitis (AKC) initial surface of the eye data from the first two patients, treated topically, nomacopan (Coversin) demonstrated:?  No serious drug related adverse events and good tolerability?  Rapid improvement in mean comfort and composite efficacy endpoint scores compared to baseline on cyclosporin?  In allergic conju Show less Read more
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