Albireo Reports Data on Pharmacodynamic Marker for A4250 in Children with Cholestatic Liver Disease at The International Liver Congress™ 2018
Albireo Pharma, Inc. (ALBO)
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Source: GlobeNewswire
— Correlation observed between reduction in serum bile acids and autotaxin with A4250 — — Autotaxin has potential to be important biomarker of cholestatic pruritus — BOSTON, April 14, 2018 (GLOBE NEWSWIRE) -- Albireo Pharma, Inc. (Nasdaq:ALBO), a clinical-stage orphan pediatric liver disease company developing novel bile acid modulators, announced that data on a pharmacodynamic marker measured in its completed Phase 2 clinical trial evaluating lead product candidate A4250 in children with cholestatic liver disease and pruritus were presented today by trial investigator Emmanuel Gonzalès, M.D., Ph.D., during a poster session at the European Association for the Study of the Liver (EASL) The International Liver Congress 2018 in Paris. The lysophospholipase autotaxin (ATX) and its product, lysophosphatic acid, have been shown to be increased in patients with pruritus due to cholestasis. In this study, treatment with A4250 decreased ATX levels in most patients, and there was a statist
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