Alder Biopharmaceuticals: Pure Play Migraine Prevention Treatment In A Crowded Space [Seeking Alpha]
ALDER BIOPHARMACEUTICALS INC (ALDR)
Last alder biopharmaceuticals inc earnings: 8/6 04:07 pm
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US:NASDAQ Investor Relations:
investor.alderbio.com/node/5806
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Source: Seeking Alpha
Summary The Migraine prevention market is estimated to be around $8 billion . Based on the number of migraineurs and the cost per treatment, that might be low. Three new preventative treatments, Lilly's Emgality, Amgen/Novartis Aimovig, and Teva's Ajovy, have been approved in 2018. These are all based on CRGP inhibitors. Initial uptake is high. Alder's ( ALDR ) migraine prevention treatment, eptinezumab (Epti) is also a CGRP inhibitor, but has some positive differentiating factors. Epti binds to the CGRP ligand and the others bind and block of CGRP receptor, and Epti is 100% bioavailable upon infusion, versus about 60% bioavailability for the others with some delay in effectiveness. Epti also appears to be more effective, particularly in those migraineurs having more than 15 episodes per month. ALDR are currently planning to submit a BLA for Epti in Q1 2019, with an expected product launch in 2020. Due to clinical differentiation, ALDR are targeting 5-7 million high
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