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Allakos Announces Positive Phase 1 Results with AK002 in Indolent Systemic Mastocytosis

Allakos Inc. (ALLK) 
Last allakos inc. earnings: 11/12 04:01 pm Check Earnings Report
US:NASDAQ Investor Relations: investor.allakos.com/investor-relations
Company Research Source: GlobeNewswire
REDWOOD CITY, Calif., Feb. 19, 2019 (GLOBE NEWSWIRE) -- Allakos Inc. (NASDAQ: ALLK), a biotechnology company developing AK002 for the treatment of eosinophil and mast cell related diseases, today announced positive multiple dose Phase 1 results in patients with indolent systemic mastocytosis (ISM), a debilitating disorder caused by the release of inflammatory mediators from mast cells. The multiple dose portion of the Phase 1 study enrolled 11 patients with ISM who had an unsatisfactory response to antihistamine and steroid treatment. Patients were enrolled in two cohorts and received open label AK002 doses of 1 mg/kg monthly for 6 months (cohort 9) or 1 mg/kg for the first month, followed by monthly doses of 3 to 10 mg/kg for 5 additional doses (cohort 10). Symptoms were collected daily using three ISM questionnaires: Mastocytosis Questionnaire (MSQ), Mastocytosis activity and symptom severity questionnaire (MAS2), and Mastocytosis Quality of Life questionnaire (MC-QoL). B Show less Read more
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