Aptose Presents New Preclinical Data on CG’806 pan-FLT3/pan-BTK Inhibitor at ASH 59th Annual Meeting [Canadian Business Journal (Canada)]
Aptose Biosciences, Inc. - Common Shares (APTO)
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Source: Canadian Business Journal
Aptose Presents New Preclinical Data on CG’806 pan-FLT3/pan-BTK Inhibitor at ASH 59th Annual Meeting SAN DIEGO and TORONTO, Dec. 11, 2017 (GLOBE NEWSWIRE) — Aptose Biosciences Inc. (NASDAQ: APTO ) (TSX: APS ) today announced the presentation of preclinical data from research led by The University of Texas MD Anderson Cancer Center demonstrating that CG’806, a highly potent pan-FLT3/pan-BTK inhibitor, exerts a profound anti-leukemia effect in human and murine leukemia cell lines harboring FLT-3 ITD mutations, mutations that are usually associated with very poor prognoses in leukemia patients. In addition, CG’806 demonstrates apoptosis, or programmed cell death, in AML patient samples by several mechanisms and is able to overcome resistance that is seen with other FLT3 inhibitors. The data were highlighted in poster presentations on Sunday and Monday, December 10 and 11, 2017 at the American Society of Hematology (ASH) 59 th Annual Meeting & Exposition, being held December 9-1
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