AstraZeneca flop a fresh blow to cancer immunotherapy combination [Reuters (UK)]
AstraZeneca PLC - American Depositary Shares (AZN)
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Source: Reuters
AstraZeneca flop a fresh blow to cancer immunotherapy combination | Reuters 4 Min Read LONDON (Reuters) - The concept of combining two immunotherapy drugs to fight lung cancer - not so long ago one of the hottest ideas in cancer research - has suffered a fresh blow from the failure of an AstraZeneca clinical study. Adding the company’s experimental drug tremelimumab to its existing product Imfinzi failed to slow disease progression or extend life in patients who had already received at least two previous treatments, the drugmaker said on Tuesday. Shares in AstraZeneca fell 1 percent following the news. The result of the study, known as ARCTIC, is disappointing but not a huge surprise, since evidence has been building that there may be little value in using a so-called CTLA-4 drug like tremelimumab on top of a PD-L1 such as Imfinzi. Indeed, since Imfinzi on its own showed some signs of efficacy, whereas adding tremelimumab did not, analysts believe the second drug might actually offset
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AZN
Sec Filings
- 4/11/24 - Form 6-K
- 4/11/24 - Form 6-K
- 4/8/24 - Form 6-K
- AZN's page on the SEC website