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Stock impact report

Celldex Therapeutics Initiates Phase 2 Combination Study of CDX-3379 and Cetuximab in Head and Neck Squamous Cell Carcinoma

Celldex Therapeutics, Inc. (CLDX) 
Last celldex therapeutics, inc. earnings: 11/12 08:01 am Check Earnings Report
US:NASDAQ Investor Relations: ir.celldex.com
Company Research Source: GlobeNewswire
HAMPTON, N.J., Nov. 17, 2017 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (Nasdaq:CLDX) announced today that enrollment has opened in its open-label Phase 2 study of CDX-3379 in combination with cetuximab in patients with cetuximab-refractory, advanced head and neck squamous cell carcinoma (HNSCC). CDX-3379 is Celldex’s human monoclonal antibody that selectively binds and inhibits the activity of ErbB3, also known as HER3. ErbB3 may be an important receptor regulating cancer cell growth and survival as well as resistance to targeted therapies, and it is expressed in many cancers, including HNSCC. Cetuximab, which is marketed under the brand name Erbitux®, is a monoclonal antibody that specifically binds EGFR and inhibits its signaling pathway. “ErbB3 is a central enabler for known oncogenic drivers, including EGFR, a validated target with approved targeted therapeutics, such as cetuximab. Unfortunately, resistance to targeted treatments often develops, and we believe CDX-3379 may Show less Read more
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