Geron: Science And Silence [Seeking Alpha]
Constellation Pharmaceuticals, Inc (CNST)
Last constellation pharmaceuticals, inc earnings: 3/10 04:12 pm
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Source: Seeking Alpha
Geron: Science And Silence Following the breakdown of the collaboration with JNJ, Geron ( GERN Update on imetelstat in MDS Imetelstat's clinical efficacy is continuing to impress. By way of reminder, the MDS trial looked at transfusion dependency following imetelstat treatment in non-del 5Q lower risk (low + intermediate-1) MDS patients that were relapsed/refractory to erythropoiesis stimulating agents. Figure 1. from the June 2019 KOL event According to a recent presentation (Figure 1), 8-week transfusion-independence ("TI") rates increased from 37% to 42% (16/38) as the data matured. In addition, 11 patients (29%) were still transfusion independent by 24-weeks, which is remarkable. That being the case, there is one interesting point to note - imetelstat performed much better in intermediate-1 than in low risk MDS. Figure 2. Of the 38 patients, 14 and 24 patients had intermediate-1 and low risk MDS respectively. However, of the 16 8-week TI responders, only 5 had low risk MDS (~21% o
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