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Homology Medicines Presents Data Showing Single Dose HMI-102 Resulted in Long-Term Correction of PKU, Including Reduction of Phe and Increased Brain Neurotransmitters in Murine Model

Homology Medicines, Inc. (FIXX) 
Last homology medicines, inc. earnings: 3/12 04:10 pm Check Earnings Report
Company Research Source: GlobeNewswire
- Phase 1/2 pheNIX Study of Gene Therapy Candidate HMI-102 is Underway and Initial Clinical Data is Anticipated by Year End - BEDFORD, Mass., June 17, 2019 (GLOBE NEWSWIRE) -- Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today the presentation of data highlighting the ability of a single administration of HMI-102, the Company’s lead AAVHSC15 gene therapy candidate for the treatment of phenylketonuria (PKU) in adults, to achieve long-term correction of PKU in PAHenu2 mice on a normal diet. These data, presented in an oral session at the European Society of Human Genetics Conference (ESHG), also demonstrated restoration of key neurotransmitters in the brain to normal levels. PKU is an inborn error of metabolism caused by a mutation in the PAH gene that results in a potentially toxic buildup of phenylalanine (Phe), an essential amino acid derived primarily from dietary protein. Homology recently announced the initiation of the pheNIX study, a Phase 1 Show less Read more
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