Biogen trial of ALS drug fails main goal, but company says data are encouraging [Financial Post (Toronto, Ontario, Canada)]
Ionis Pharmaceuticals, Inc. (IONS)
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Source: Financial Post
to reach its main goal, but secondary measures and biomarkers showed favorable trends, the company said on Sunday. Biogen will engage with regulators and other stakeholders “to understand the meaningfulness of this data and potential paths forward,” Toby Ferguson, head of the neuromuscular development unit at Biogen, told Reuters. The company is treating trial patients in a follow-on study and recently launched a Phase 3 trial of the drug, tofersen, in patients who are not yet experiencing ALS symptoms. 16 best online deals in the Canadian retail space right now Advertisement Advertisement Article content Tofersen, administered directly into the spinal canal each month, is designed to suppress the production of SOD1, a protein that can accumulate to toxic levels in ALS patients with mutations in a specific gene. Around 2% of ALS cases are believed to be caused by the genetic mutation. After 28 weeks of treatment, the 108-patient trial showed a 1.2-point difference on a s
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IONS
Earnings
- 2/21/24 - Beat
IONS
Sec Filings
- 4/17/24 - Form 4
- 4/17/24 - Form 4
- 4/16/24 - Form 144
- IONS's page on the SEC website