Sotagliflozin Data from Pivotal inTandem1 and inTandem2 Studies in Patients with Type 1 Diabetes Presented at ADA 2017
Lexicon Pharmaceuticals, Inc. (LXRX)
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Source: PR Newswire
THE WOODLANDS, Texas, June 10, 2017 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) today announced data from its two pivotal sotagliflozin studies, inTandem1 and inTandem2, being presented at the 77th American Diabetes Association (ADA) Scientific Sessions in San Diego, CA.Collectively, 24-week data from the two pivotal inTandem1 and inTandem2 studies for sotagliflozin in patients with type 1 diabetes demonstrated the following:Sotagliflozin 200 mg and 400 mg on top of optimized insulin significantly reduced A1C compared to placebo (pSotagliflozin was generally well tolerated. In both studies, there was a low rate of severe hypoglycemia, which occurred less frequently on sotagliflozin than placebo in three of four arms across the two studies. In both studies, there was a low diabetic ketoacidosis (DKA) rate (0.4% to 3.1% over 24 weeks) that was higher for patients on insulin pump versus multiple dose injections (MDI). inTandem1 Study – "Twenty-Four Week Efficacy and Saf
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