Magenta up 15% on promising data on ADC conditioning agent [Seeking Alpha]
Magenta Therapeutics, Inc. (MGTA)
Last magenta therapeutics, inc. earnings: 11/13 08:00 am
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Source: Seeking Alpha
Healthcare | On the Move Magenta up 15% on promising data on ADC conditioning agent Dec. 10, 2019 12:00 PM ET Magenta Therapeutics, ... (MGTA) Douglas W. House Thinly traded Magenta Therapeutics ( +14.7% preclinical data An NIH scientist presented data that showed the first-ever successful transplant of gene-modified cells in non-human primates without chemo or radiation preconditioning via the use of a targeted single-agent antibody-drug conjugate (ADC). Chemo and radiation are typically used to kill disease-causing cells before treatment, a paradigm saddled with severe side effects like toxicity and infertility. A single dose of CD117-ADC achieved the same level of depletion as four doses of chemo agent busulfan, enabling the successful engraftment and persistence of stem cells with the ß-globin gene, mutations of which cause sickle cell disease and ß-thalassemia, without the toxic side effects. Vector copy number was stable beyond three months. The single dose of CD117-ADC depleted
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