NantKwest and ImmunityBio Announce Complete Response in Metastatic Pancreatic Cancer in the First Patient to Receive PD-L1 Tumor-Targeted Natural Killer Cells (PD-L1.t-haNK) Combined with ...
NANTKWEST (NK)
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Source: Business Wire
World’s first combination of tumor-targeted, off-the-shelf PD-L1-targeted Natural Killer cells with IL-15 fusion protein (N-803) to induce immune system activation of both the NK and T-cells demonstrated complete response in second-line metastatic pancreatic cancer, confirmed by PET/CT scan.Results consistent with durable complete responses recently reported in Triple Negative Breast Cancer (TNBC) when off-the-shelf CD-16 NK therapy was combined with ImmunityBio’s N-803.Over 130 doses of PD-L1.t-haNK cells safely administered in Phase 1 trial with no severe treatment-related adverse side effects.NantKwest plans to initiate registration trials in recurrent metastatic TNBC and pancreatic cancer patients that failed standard of care.N-803 received Breakthrough Designation from the FDA for BCG Unresponsive CIS non-muscle invasive bladder cancer.NantKwest plans to apply for Breakthrough Therapy Designation for advanced TNBC and pancreatic cancer. CULVER CITY, Calif.--(BUSINESS WIRE)--N
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