Opiant Pharmaceuticals Announces Publication of New Pre-Clinical Data Supporting Potential of OPNT005 as a Heroin Vaccine
Opiant Pharmaceuticals, Inc. (OPNT)
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Source: GlobeNewswire
Data Published Online in Journal of Medicinal Chemistry Company Evaluating Potential Clinical Program for OPNT005 SANTA MONICA, Calif., Dec. 18, 2017 (GLOBE NEWSWIRE) -- Opiant Pharmaceuticals, Inc. (“Opiant”) (NASDAQ:OPNT), a specialty pharmaceutical company developing pharmacological treatments for addictions, today reports that new pre-clinical data supporting the continued development of OPNT005 as a heroin vaccine were published online in the Journal of Medicinal Chemistry (http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01427). The study describes an improved synthesis of a heroin-like molecule (a hapten) that is an essential component of OPNT005, which would make it practical to scale the synthesis of this molecule for clinical use. Additionally, OPNT005 produced high levels of antibodies in rodents. These antibodies cross react with heroin and other abused opioids, including oxycodone and hydrocodone. The pharmacological effects of intravenous heroin were signi
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