Protagonist Therapeutics Receives $1.34 Million SBIR Funding for Development of Biomarkers of IL-23 Receptor Antagonist Activity
Protagonist Therapeutics, Inc. (PTGX)
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Source: PR Newswire
NEWARK, Calif., May 24, 2017 /PRNewswire/ -- Protagonist Therapeutics, Inc. (Nasdaq: PTGX) today announced the receipt of a Phase 2 Small Business Innovation Research (SBIR) Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). This award, Number 2R44DK104445-02, provides up to $1.34 million over two years to support research aimed at developing biomarkers that define IL-23 receptor (IL-23R) target engagement by oral peptide antagonists and the effects of that engagement on downstream signaling. Such biomarkers can be used for demonstrating early pharmacodynamics clinical proof-of-concept and estimating effective dose range for the treatment of inflammatory bowel diseases (IBD) with anti-IL-23R agents, including Protagonist's oral peptide drug candidate, PTG-200. The company expects to initiate human clinical testing of PTG-200 in the second half of 2017. Protagonist's research has sh
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