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Stock impact report

Syros Pharma's lead candidate fails to impress in mid-stage blood cancer study; shares down 48% premarket [Seeking Alpha]

Syros Pharmaceuticals, Inc. (SYRS) 
Last syros pharmaceuticals, inc. earnings: 3/5 06:57 am Check Earnings Report
US:NASDAQ Investor Relations: ir.syros.com
Company Research Source: Seeking Alpha
Syros Pharma's lead candidate fails to impress in mid-stage blood cancer study; shares down 48% premarketThinly traded micro cap Syros Pharmaceuticals (NASDAQ:SYRS) slumps48% premarket on increased volume in response topreliminary data from a Phase 2 clinical trial assessing lead candidate SY-1425 (tamibarotene) in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The results were presented as ASH in Atlanta, GA.Out of 48 evaluable patients (23 with AML and 25 with MDS), there was only one complete responder. 10 AML and two MDS patients showed "evidence of clinical activity."On the safety front, most adverse events (AEs) were mild or moderate. The most common Grade 3 (serious) or Grade 4 (life-threatening) AE was abnormally high blood triglycerides (16%).Development is ongoing.Tamibarotene is a selective retinoic acid receptor alpha agonist.See all stocks on the move » Show less Read more
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