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Stock impact report

Zymeworks' lead candidate shows positive action in early-stage study; shares up 1% [Seeking Alpha]

Zymeworks Inc. (ZYME) 
Last zymeworks inc. earnings: 3/2 04:15 pm Check Earnings Report
US:NYSE Investor Relations: ir.zymeworks.com/overview
Company Research Source: Seeking Alpha
Zymeworks' lead candidate shows positive action in early-stage study; shares up 1%Preliminary results from a Phase 1 dose-escalation study evaluating Zymeworks' (ZYME+1%) lead candidate ZW25 in patients with HER2-expressing cancers showed a treatment effect. The data will be presented on Friday, December 8 at the San Antonio Breast Cancer Symposium.A total of 22 patients are enrolled, 11 with breast cancer, eight with gastric, gastroesophageal junction or esophageal (GE) cancer and three with other HER2-expressing cancers.The partial response rate was 27% (n=6/22) across all dose groups. In breast cancer patients who received a median of six prior lines of HER2-targeted therapy, the partial response rate was 56% (n=5/9) in those with measurable disease with 89% (n=8/9) showing decreases in target lesions.Three HER2-high GE cancer patients with measurable disease showed tumor shrinkage, including one partial responder and one with stable disease after six months.79% (n=11/14) of breast Show less Read more
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