Synlogic Announces Nature Publication Demonstrating Novel Application of Synthetic Biotic Platform
Synlogic, Inc. (SYBX)
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Source: PR Newswire
CAMBRIDGE, Mass., Oct. 12, 2021 /PRNewswire/ -- Synlogic, Inc. (Nasdaq: SYBX), a clinical stage company bringing the transformative potential of synthetic biology to medicine, today announced the publication in Nature of preclinical research with live biotherapeutic products designed using the Company's Synthetic Biotic™ platform. In the study, a live biotherapeutic product modulated the tumor microenvironment and increased susceptibility to immunotherapy in a murine model. The research was led by Synlogic collaborators and Professor Roger Geiger of the Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland. The paper, "Metabolic modulation of tumours with engineered bacteria for immunotherapy" demonstrated that, following intratumoral injection in a murine model, a live biotherapeutic Escherichia coli Nissle 1917 strain engineered to convert ammonia to L-arginine colonized and was active within the tumor microenvironment. Administration of t
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