TESARO's niraparib shows treatment effect in late-line ovarian cancer [Seeking Alpha]
TESARO (TSRO)
Last tesaro earnings: 11/1 04:05 pm
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Source: Seeking Alpha
TESARO's niraparib shows treatment effect in late-line ovarian cancerTESARO (NASDAQ:TSRO)announces successful results from a late-stage study, QUADRA, evaluating ZEJULA (niraparib) in heavily pretreated ovarian cancer patients with and without BRCA mutations.QUADRA, a single-arm, 461-subject trial, assessed niraparib in a fourth line+ setting. 92% (n=424) of the participants were PARP inhibitor-naive. 15% (n=64) of this group were BRCA mutation-positive and 85% (n=360) were BRCA-negative. 63% (n=267) were previously treated with Roche's Avastin (bevacizumab).The objective response rate (ORR) was 29% (n=13/45) in fourth- and fifth-line HRD-positive patients not previously treated with a PARP inhibitor who were platinum-sensitive. The median duration of response was 9.2 months. HRD (homologous recombination deficiency) is another type of mutation in ovarian cancer.In fourth/fifth-line patients with BRCA mutations (including platinum-sensitive, resistant and refractory), the ORR was 31%
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