Intrexon on go to start clinical study of novel approach to treat type 1 diabetes [Seeking Alpha]
INTREXON CORP (XON)
Last intrexon corp earnings: 11/12 07:30 am
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Intrexon on go to start clinical study of novel approach to treat type 1 diabetesThe FDA hassigned off on Intrexon (XON-2.8%) subsidiary ActoBio Therapeutics' IND, allowing the initiation of a Phase 1b/2a clinical trial evaluating AG019 for the treatment of early-onset type 1 diabetes (T1D).The company says orally administered AG019 is an innovative disease-modifying approach to treat T1D. The capsule formulation contains engineeredLactococcus lactis (L. lactis), a Gram-positive bacterium used in the production of buttermilk and cheese, human proinsulin and the anti-inflammatory proteininterleukin-10 (IL-10). It is designed to reduce T1D pathology by re-establishing immunological tolerance to islet antigens via the production of regulatory T cells.Pancreatic islets are clusters of cells that produce insulin.Preclinical studies showed a significant diabetes remission rate when treatment started at an early stage. When combined with short-term treatment with an anti-CD3 monoclonal antib
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