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Stock impact report

Arbutus up 3% after hours on encouraging data on HBV candidate AB-506 [Seeking Alpha]

Arbutus Biopharma Corporation (ABUS) 
Last arbutus biopharma corporation earnings: 11/6 07:30 am Check Earnings Report
US:NASDAQ Investor Relations: investor.arbutusbio.com/node/5806
Company Research Source: Seeking Alpha
Arbutus Biopharma (NASDAQ: ABUS ) perks up   after hours in reaction to positive data from a Phase 1a/1b clinical trial evaluating HBV capsid inhibitor AB-506 in healthy volunteers and two cohorts with chronic hepatitis B virus (HBV) infection. In the healthy subjects, no serious treatment-related adverse events were reported. Liver function test remained normal throughout the 10-day dosing period. In the hepatitis B groups, mean HBV DNA decreased 100-fold to ~630-fold (160 mg, 400 mg doses) at day 28 while HBV RNA decreased ~250-fold in both dose cohorts. On the safety front, four HBV subjects experienced life-threatening flares in the liver enzyme ALT (biomarker for liver damage) which returned to baseline after treatment was completed or discontinued. Another liver enzyme, AST, spiked to a lesser degree. None met the criteria for induced liver injury since bilirubin and liver synthetic function remained normal. Detailed results will be submitted for presentation a Show less Read more
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