Achillion’s ACH-5228 Achieves Positive Results in Phase 1 Multiple Ascending Dose Study in Healthy Volunteers
ACHISON INC A (ACHN)
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Source: GlobeNewswire
ACH-5228 delivers near complete and sustained inhibition of the complement alternative pathway Twice-daily oral administration to move forward in Phase 2 trials Investigational New Drug (IND) application to be submitted in fourth quarter of 2019 BLUE BELL, Pa., July 22, 2019 (GLOBE NEWSWIRE) -- Achillion Pharmaceuticals, Inc. (Nasdaq: ACHN), a clinical-stage biopharmaceutical company dedicated to transforming the lives of patients and families affected by complement-mediated diseases, today announced results from their Phase 1 multiple ascending dose (MAD) study with ACH-5228 outside of the United States. In the randomized Phase 1 MAD study, ACH-5228 was administered to 43 healthy volunteers. Study subjects received oral doses of ACH-5228 ranging from 40 mg to 200 mg twice a day (BID) for fourteen days. The study also included a single dose cohort of 240 mg. The results demonstrated that ACH-5228, when dosed 120 mg BID or higher, achieved near complete and sustained Alternative Pa
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