Achillion Reports Preliminary Proof-of-Concept With ACH-4471 for the Treatment of C3G
ACHISON INC A (ACHN)
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Source: GlobeNewswire
- Greater than 50% improvement in proteinuria (albumin to creatinine ratio) after 14 days of oral dosing with ACH-4471 - - Improvement in complement alternative pathway biomarkers observed - NEW HAVEN, Conn., Nov. 14, 2017 (GLOBE NEWSWIRE) -- Achillion Pharmaceuticals, Inc. (Nasdaq:ACHN) today reported preliminary proof-of-concept results from group 1 of its ongoing Phase 2, open-label, 14-day study of ACH-4471 for patients with C3 glomerulopathy (C3G) or immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN). The Principal Investigator for this study is Dr. Tom Barbour, Royal Melbourne Hospital, Melbourne, Australia, Department of Nephrology. This trial, initiated in September 2017, has currently completed treatment of the first group consisting of two sentinel patients. Interim data from the two sentinel patients in this ongoing trial demonstrated that ACH-4471 achieved complement alternative pathway (AP) inhibition resulting in a greater
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