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Stock impact report

Health~Holland Awards Another Innovative Research Grant for DNA Pol IIIC Inhibitors to Leiden University Medical Center and Acurx Pharmaceuticals

Acurx Pharmaceuticals, Inc. (ACXP) 
Company Research Source: PR Newswire
The objective of this new phase of collaboration with Leiden University Medical Center (LUMC) is to further advance the recently completed and published pioneering research to determine whether the modes of DNA polymerase pol IIIC (PolC) action and resistance are conserved across important species of Gram-positive multidrug resistant organisms The previous LUMC-Acurx Health~Holland project successfully elucidated the structure of PolC from E. faecium, a critical Gram-positive human pathogen, in complex with two Acurx pol IIIC inhibitors. These data, using both Acrux's Phase 3-ready ibezapolstat for treatment of C. difficile infection and an advanced preclinical pol IIIC inhibitor from the ongoing discovery program, defined for the first time the structural biology of inhibition at the enzyme target using cryo-electron microscopy This new grant will enable extending mechanistic research into pol IIIC inhibition to acce Show less Read more
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