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Adagene Spotlights ADG126+KEYTRUDA Data, Late-Line MSS-CRC Focus in Oppenheimer Conference Talk [Yahoo! Finance]

Adagene Inc. - ADS, each representing 1.25 ordinary shares (ADAG) 
Company Research Source: Yahoo! Finance
The company is developing ADG126 as a “masked” anti-CTLA-4 antibody intended to improve the safety of CTLA-4 blockade while enabling higher dosing in combination regimens, particularly with Merck's KEYTRUDA (pembrolizumab). Focus on late-line MSS colorectal cancer without liver metastases Chane-Du said Adagene's initial clinical focus is late-line microsatellite stable colorectal cancer (MSS-CRC) in patients without liver metastases, a setting he described as having low response rates to current standards of care and poor overall survival outcomes. He noted that PD-1 therapies have not shown meaningful activity in MSS-CRC as monotherapy in prior studies and that there is no KEYTRUDA label for this patient population. ? Hinge Health's AI Moat Might Be Its Patient Movement Data Within this subgroup, Adagene is evaluating ADG126 plus full-dose pembrolizumab across multiple dose schedules. Chane-Du said patients without liver metastases represent roughly 30% of MSS-CRC cases, whic Show less Read more
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