Updated Data from Phase 1b/2 Study of Muzastotug in Combination with KEYTRUDA® (pembrolizumab) in Late-line Patients with Microsatellite Stable Colorectal Cancer Demonstrate Improved Durab...
Adagene Inc. - ADS, each representing 1.25 ordinary shares (ADAG)
Company Research
Source: GlobeNewswire
Dose-Dependent Efficacy Results: As of the latest data cut, muzastotug achieved a 31% (8/26) confirmed overall response rate (ORR) in the combined 20 mg/kg dose cohorts, showing a clear improvement over the 13% ORR (5/39) in the combined 10 mg/kg dose cohorts Extended Durability: Median duration of response (mDOR) was not yet reached in the 20 mg/kg cohorts, with responses ongoing beyond 9 months; confirmed mDOR of 6.2 months in the 10 mg/kg cohorts Meaningful Progression-Free Survival (PFS): Median PFS was 6.7 months in the combined 20 mg/kg cohorts, outperforming the 4.8 months observed in the combined 10 mg/kg cohorts Favorable Overall Survival Results: In the 10 mg/kg cohorts (n=41; median follow-up, 23.8 months), median overall survival was 19.8 months, with 48% of patients alive at two years, showing the long-tail survival typical of CTLA-4 immunotherapy. At 20 mg/kg, one-year survival was 80.8% vs. 70.1% at 10 mg/kg Expanded Therapeutic Window: Across 67 patients in all co
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News
- Adagene (ADAG) had its price target raised by Guggenheim from $9.00 to $10.00. They now have a "buy" rating on the stock.MarketBeat
- Adagene Announces Pricing of US$70.0 Million Public Offering of ADSs [Yahoo! Finance]Yahoo! Finance
- Adagene announces pricing of $70M public offering of ADS [Seeking Alpha]Seeking Alpha
- Adagene Announces Pricing of US$70.0 Million Public Offering of ADSsGlobeNewswire
- Adagene Announces Clinical Collaboration with Incyte to Evaluate Muzastotug (ADG126) in Combination with Incyte’s TGFßR2xPD-1 Bispecific Antibody (INCA33890) in Patients with Microsatellite Stable Colorectal Cancer (MSS CRC)GlobeNewswire
ADAG
Sec Filings
- 4/2/26 - Form 424B5
- 4/2/26 - Form 6-K
- 4/2/26 - Form 424B5
- ADAG's page on the SEC website