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-0.000909918107370317 -0.00181983621474063 -0.00272975432211095 -0.00318471337579619 -0.00136487716105556 -0.00591446769790714 -0.00136487716105556 0.000454959053685239
Stock impact report

Agios (AGIO) Meets Clinical Proof-of-Concept in Anemia Treatment [Yahoo! Finance]

Agios Pharmaceuticals, Inc. (AGIO) 
Last agios pharmaceuticals, inc. earnings: 4/30 07:00 am Check Earnings Report
US:NASDAQ Investor Relations: investor.agios.com/investor-overview
Company Research Source: Yahoo! Finance
pyruvate kinase (PK) activator AG-946 to treat anemia in adults with lower-risk myelodysplastic syndromes (MDS). A total of 22 patients were enrolled in this phase IIa portion and classified into two cohorts — 12 classified as non-transfused (NTD) and 10 classified as low transfusion burden (LTB). The primary endpoints of the study were transfusion dependence (applicable only for the LTB cohort) and hemoglobin response. Data from the phase IIa portion of the study revealed that 40% of patients in the LTB cohort achieved the transfusion independence endpoint. In contrast, one of the 22 patients treated in the study achieved the hemoglobin response endpoint in the 16-week treatment (core) period. Per Agios, these results highlight the potential of AG-946 by improving red blood cell (RBC) health through its unique mechanism of action. A significant reduction in transfusions allows patients to potentially lower visits to the clinic, thereby improving their quality of life. The saf Show less Read more
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