AGTC Presents Data Demonstrating Efficiency of its AAV Vectors for Ocular Gene Therapy Even in the Presence of Anti-AAV Antibodies
Applied Genetic Technologies Corporation (AGTC)
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Source: GlobeNewswire
-Data support safety and potential clinical utility of AGTC’s ocular gene therapy candidates regardless of patients’ AAV antibody status- GAINESVILLE, Fla., and CAMBRIDGE, Mass., Oct. 21, 2019 (GLOBE NEWSWIRE) -- Applied Genetic Technologies Corporation (Nasdaq: AGTC), a biotechnology company conducting human clinical trials of adeno-associated virus (AAV)-based gene therapies for the treatment of rare diseases, today reported new data from non-clinical studies evaluating the effect of pre-existing anti-AAV antibodies on the transduction and expression efficiency of AAV vectors. Results show that the presence of neutralizing antibodies (NAbs) to AAV in the serum or in the eye did not affect gene delivery, gene expression, or inflammation following ocular administration of AAV vectors. The data will be presented in a poster at the European Society of Gene and Cell Therapy (ESGCT) taking place in Barcelona, October 22 – 25. “Preexisting immunity to AAV remains a challenge for ma
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