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PeptiDream and Alnylam Announce Achievement of Key Milestone in siRNA Conjugate Discovery Collaboration Demonstrating Peptide-Ligand Mediated Targeted siRNA Delivery to Specific Extrahepat...

Alnylam Pharmaceuticals, Inc. (ALNY) 
Last alnylam pharmaceuticals, inc. earnings: 2/6 08:00 am Check Earnings Report
US:NASDAQ Investor Relations: investors.alnylam.com/investor-overview
Company Research Source: Yahoo! Finance
Reid, hereinafter "PeptiDream")(Tokyo: 4587), announced the achievement of a preclinical development milestone in its collaboration with Alnylam Pharmaceuticals, Inc. ("Alnylam"). The significant milestone marks a key step in building a modular therapeutic platform for precision siRNA delivery using macrocyclic peptides that is adaptable across numerous therapeutic areas and offers a scalable solution to expand to scope of RNAi therapeutics. This milestone underscores the transformative potential of PeptiDream's proprietary Peptide Discovery Platform System ® (PDPS) in enabling receptor-mediated uptake of siRNA therapeutics into organs beyond the liver—a long-standing challenge in the field of RNA interference (RNAi). The peptide-siRNA conjugate demonstrated robust and specific uptake with deep target gene knockdown in wild-type animal models via subcutaneous administration, with negligible activity in receptor knockout models, confirming the specificity of the targeting mechanism. Show less Read more
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