Aptose Presents Preclinical Data on APTO-253 at 2018 AACR Annual Meeting
Aptose Biosciences, Inc. - Common Shares (APTO)
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Source: GlobeNewswire
CHICAGO and SAN DIEGO and TORONTO, April 17, 2018 (GLOBE NEWSWIRE) -- Aptose Biosciences Inc. (NASDAQ:APTO) (TSX:APS) today announced the presentation of preclinical data exploring the mechanism of action of APTO-253, the company’s clinical stage product candidate. The data, demonstrating heightened sensitivity of BRCA1 or BRCA2 mutated cancer cells to APTO-253, were presented in a poster Tuesday, April 17 at the 2018 American Association for Cancer Research (AACR) Annual Meeting being held April 14-18, in Chicago, IL. The poster, entitled APTO-253 is a new addition to the repertoire of drugs that can exploit DNA BRCA1/2 deficiency, explored the mechanism of action of APTO-253, a small molecule with anti-proliferative activity against cell lines derived from a wide range of human malignancies. This study investigated the mechanism of action of APTO-253 to identify synthetic lethal interactions that can guide combination drug studies. The research team found that APTO-253 stabil
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