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0 0.00241545893719823 0.00241545893719823 0.00241545893719823 -0.00241545893719802 -0.00241545893719802 -0.0120772946859903 -0.00724637681159405
Stock impact report

Aquestive receives FDA CRL for Anaphylm allergic reaction treatment [Yahoo! Finance]

Aquestive Therapeutics, Inc. (AQST) 
Last aquestive therapeutics, inc. earnings: 3/11 04:30 pm Check Earnings Report
US:NASDAQ Investor Relations: investors.aquestive.com/investor-relations
Company Research Source: Yahoo! Finance
The therapy aims to treat Type I allergic reactions, including anaphylaxis, in patients weighing 30kg or more. The CRL highlights deficiencies in human factors validation for Anaphylm, such as incorrect film placement and difficulty opening the pouch, which the FDA indicated could cause safety risks during anaphylaxis. Aquestive has modified the packaging and instructions for use and will conduct a new human factors validation study with these updates. The company will also address tolerability concerns in its resubmission. No concerns were raised about comparability data or chemistry, manufacturing, and controls (CMC) in the CRL. However, due to changes in human factors requirements, the FDA has requested a single pharmacokinetics (PK) study to assess any packaging or labelling modifications. The agency stated that human factors and PK studies may proceed concurrently. Aquestive intends to request a Type A meeting with the FDA to review options for resubmission and expects Show less Read more
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