Aravive Announces Initiation of Investigator-Sponsored Phase 1/2 Study of AVB-500 in Combination with Avelumab in Patients with Advanced Urothelial Carcinoma (COAXIN)
Aravive, Inc. (ARAV)
Last aravive, inc. earnings: 3/27 08:00 am
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Source: GlobeNewswire
HOUSTON, March 24, 2020 (GLOBE NEWSWIRE) -- Aravive, Inc. (Nasdaq: ARAV), a clinical-stage biopharmaceutical company, announced that the first patient has been dosed in an investigator-sponsored Phase 1/2 clinical trial of the company’s GAS6/AXL inhibitor AVB-500 in combination with PD-L1 inhibitor avelumab in patients with advanced urothelial carcinoma (UC). The study is being led by Abhishek Tripathi, M.D., Assistant Professor of Medicine, Section of hematology/oncology at the University of Oklahoma Stephenson Cancer Center. “Locally advanced or metastatic urothelial carcinoma is an aggressive cancer with poor long-term survival,” said Dr. Tripathi. “Although immunotherapy results in durable responses in some patients, only a small proportion of patients respond and most eventually progress. Targeting additional mechanisms of immunosuppression and tumor growth such as GAS6/AXL signaling could be synergistic with immunotherapy and may improve outcomes in this challenging disease.”
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