Korea University Researchers Revive an Abandoned Depression Drug Target Using Structurally Novel NK1 Receptor Inhibitors [Yahoo! Finance]
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Source: Yahoo! Finance
SEOUL, South Korea Jan. 14, 2026 /PRNewswire/ -- Researchers report that redesigning neurokinin-1 receptor (NK1R) antagonists can restore antidepressant-like effects in animal models. Using machine-learning-guided screening, the team identified structurally distinct compounds that lack chemical features found in earlier failed drugs. In mouse models of stress- and inflammation-induced depression, the lead compound reduced depressive-like behavior and brain inflammation without affecting locomotion. The findings suggest that NK1R remains a viable therapeutic target when approached with improved molecular design. For decades, scientists have investigated the neurokinin-1 receptor (NK1R) as a potential target for treating major depressive disorder. Early studies suggested promise, but enthusiasm faded after clinical trials of drugs such as aprepitant failed to show clear benefits, raising doubts about whether NK1R itself was a viable antidepressant target. Now, researchers from Kore
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