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Stock impact report

AstraZeneca to acquire China rights for AbelZeta's CAR-T therapy [Yahoo! Finance]

AstraZeneca PLC - American Depositary Shares (AZN) 
Last astrazeneca plc - american depositary shares earnings: 2/5 04:00 pm Check Earnings Report
US:NYSE Investor Relations: astrazeneca.com/investor-relations.html
Company Research Source: Yahoo! Finance
The acquisition gives AstraZeneca full global control over the development, manufacturing, and commercialisation of the therapy. AbelZeta will receive up to $630m from AstraZeneca, including upfront payments and milestone fees for the GPC3 programme in China. AstraZeneca previously held rights to C-CAR031 outside of China. AbelZeta remains eligible for additional milestone payments and royalties for development outside of China. C-CAR031, an autologous CAR-T therapy targeting Glypican 3 (GPC3), is designed using AstraZeneca's dominant negative transforming growth factor-beta receptor II armouring platform. It is currently under investigation for treating hepatocellular carcinoma (HCC) and other solid tumours. Liver cancer ranks as the third-leading cause of cancer death globally, with HCC being the predominant form, comprising approximately 75% of all primary liver cancers in adults. HCC tends to begin in the liver as a single tumour or multiple nodules, treatable at a loca Show less Read more
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