Vividion Publishes Discovery of WRN Inhibitor VVD-214 in Journal of Medicinal Chemistry [Yahoo! Finance]
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Source: Yahoo! Finance
In preclinical studies, VVD-214 was well tolerated and led to robust tumor regression in multiple models of MSI-high colorectal cancer Findings highlight the power of Vividion's chemoproteomics and covalent-first approach to drug discovery to address challenging cancer targets SAN DIEGO, January 06, 2026 BUSINESS WIRE Vividion Therapeutics , Inc. (Vividion), a clinical-stage biopharmaceutical company, and a wholly owned and independently operated subsidiary of Bayer AG, today announced the publication of a manuscript detailing the discovery and optimization of VVD-214, the company's covalent inhibitor of Werner helicase (WRN), on the cover of the Journal of Medicinal Chemistry . The article, " Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers " (Kikuchi et al., J. Med. Chem. , December 2025), validates Vividion's covalent-first chemoproteomics approach to reach targets that have eluded tradit
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