BBOT Announces Late-Breaking Preclinical Data on BBO-10203, a First-in-Class RAS:PI3Ka Breaker, at the San Antonio Breast Cancer Symposium (SABCS)
BridgeBio Oncology Therapeutics, Inc. (BBOT)
Company Research
Source: GlobeNewswire
Preclinical data demonstrate BBO-10203 blocks RAS-mediated activation of PI3Ka, strongly inhibits pAKT signaling in tumor cells without inducing hyperglycemia, and shows robust anti-tumor activity both as monotherapy and in combination with standard of care therapies in mutant or wild-type PIK3CA breast cancer modelsBBOT will also present a trial in progress poster on BREAKER-101, a Phase 1 clinical trial evaluating BBO-10203 in patients with locally advanced or metastatic HER2+ breast cancer, HR+/HER2- breast cancer, KRAS mutant colorectal cancer, and KRAS mutant non-small cell lung cancer with initial Phase 1 data expected in the first half of 2026 SOUTH SAN FRANCISCO, Calif., Dec. 10, 2025 (GLOBE NEWSWIRE) -- BridgeBio Oncology Therapeutics, Inc. (“BBOT”) (Nasdaq: BBOT), a clinical-stage biopharmaceutical company focused on RAS-pathway malignancies, today announced late-breaking preclinical data on BBO-10203, a first-in-class covalent small molecule RAS:PI3Ka breaker that select
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News
- BBOT to Present at the 44th Annual J.P. Morgan Healthcare ConferenceGlobeNewswire
- BBOT Reports Inducement Grants under Nasdaq Listing Rule 5635(c)(4)GlobeNewswire
- BBOT to Participate in Upcoming December Investor Healthcare ConferencesGlobeNewswire
- BBOT Reports Third Quarter 2025 Financial Results and Update on Corporate ProgressGlobeNewswire
- BBOT to Participate in the Jefferies Global Healthcare Conference in LondonGlobeNewswire
BBOT
Sec Filings
- 12/12/25 - Form 4
- 12/8/25 - Form S-1
- 10/16/25 - Form 4
- BBOT's page on the SEC website