Preclinical Data Presented at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics Support Potential of BBO-10203, a First-in-Class RAS:PI3Ka Break...
BridgeBio Oncology Therapeutics, Inc. (BBOT)
Company Research
Source: GlobeNewswire
Data demonstrate BBO-10203 blocks RAS-mediated activation of PI3Ka and strongly inhibits pAKT signaling in tumor cells without affecting glucose metabolismRobust monotherapy activity, as well as combination activity with BBOT’s KRASG12C ON/OFF inhibitor, BBO-8520, and panKRAS inhibitor, BBO-11818, was observed at well-tolerated dose levels in a panel of KRAS-mutant modelsThe combination of a KRAS inhibitor with a PI3Ka pathway inhibitor may maximize the response rate and reduce the development of adaptive resistance mechanisms due to full inhibition of both MAPK and PI3Ka signalingBBOT-10203 is currently being evaluated in the Phase 1 BREAKER-101 trial for patients with HER2+ amplified or HR+/HER2- breast cancer, and KRAS mutant colorectal or non-small cell lung cancer with initial Phase 1 clinical data expected in the first half of 2026 SOUTH SAN FRANCISCO, Calif., Oct. 25, 2025 (GLOBE NEWSWIRE) -- BridgeBio Oncology Therapeutics, Inc. (“BBOT”) (Nasdaq: BBOT), a clinical-stage bio
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BBOT
News
- BBOT to Participate in Upcoming December Investor Healthcare ConferencesGlobeNewswire
- BBOT Reports Third Quarter 2025 Financial Results and Update on Corporate ProgressGlobeNewswire
- BBOT to Participate in the Jefferies Global Healthcare Conference in LondonGlobeNewswire
- BBOT Announces Poster Presentations at the San Antonio Breast Cancer Symposium (SABCS)GlobeNewswire
- BBOT Presents Preclinical Data Demonstrating Potential of BBO-11818 as a Potent panKRAS Inhibitor at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer TherapeuticsGlobeNewswire
BBOT
Sec Filings
- 10/16/25 - Form 4
- 10/6/25 - Form 4
- BBOT's page on the SEC website