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0 0.00476190476190483 -0.0204761904761905 0.00476190476190483 0.0223809523809525 -0.019047619047619 -0.0954761904761904 -0.0707142857142857
Stock impact report

Verve falls after early-stage data for lead asset [Seeking Alpha]

Beam Therapeutics Inc. (BEAM) 
Company Research Source: Seeking Alpha
VERVE-101 from patients with a form of dyslipidemia called heterozygous familial hypercholesterolemia (HeFH). Citing a data cut of 10 patients on October 16, Verve ( VERV ) said VERVE-101, an in vivo base editor, at the highest dose level, led up to a 55% decline in low-density lipoprotein cholesterol (LDL-C), or "bad" cholesterol. However, out of nine patients who were part of the safety analysis, there were treatment-related adverse events in the two higher-dose groups. Notably, two patients developed serious adverse events, including a myocardial infarction, which was potentially related to treatment, according to the company. The ongoing phase 1b trial called heart-1 is designed to evaluate four dose levels of VERVE-101 in adults living with HeFH and other heart-related conditions such as high cholesterol. However, the company plans to continue patient enrollment "based on favorable initial findings." Recently, Beam Therapeutics ( BEAM ) agreed to sell certain righ Show less Read more
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