Bristol Myers Squibb Announces Positive Topline Result from Pivotal Phase 3 Trial Evaluating Opdivo® (nivolumab) plus Yervoy® (ipilimumab) vs. Chemotherapy in Previously Untreated Malignan...
Bristol-Myers Squibb Company (BMY)
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Source: Business Wire
Opdivo plus Yervoy prolonged survival compared to chemotherapy at interim analysis in CheckMate -743Malignant pleural mesothelioma is a rare and aggressive cancer with limited treatment options PRINCETON, N.J.--(BUSINESS WIRE)--Bristol-Myers Squibb (NYSE: BMY) today announced that CheckMate -743, a pivotal Phase 3 trial evaluating Opdivo® (nivolumab) in combination with Yervoy® (ipilimumab) in previously untreated malignant pleural mesothelioma (MPM) met its primary endpoint of overall survival (OS). Based on a pre-specified interim analysis conducted by the independent Data Monitoring Committee, Opdivo in combination with Yervoy resulted in a statistically significant and clinically meaningful improvement in OS compared to chemotherapy (pemetrexed and cisplatin or carboplatin).The safety profile of Opdivo plus Yervoy observed in the trial reflects the known safety profile of the combination.“Malignant pleural mesothelioma is a devastating disease that has seen limited treatment a
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