The first KRAS drugs have been sluggish on the market. Will the next generation fare better? [Yahoo! Finance]
Bristol-Myers Squibb Company (BMY)
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Source: Yahoo! Finance
This story was originally published on PharmaVoice . To receive daily news and insights, subscribe to our free daily PharmaVoice newsletter When the FDA granted Amgen's KRAS drug Lumakras accelerated approval in 2021, it marked a milestone moment for a target once deemed undruggable. For decades, scientists knew that mutations of the KRAS gene accelerated several deadly types of cancer, but the resulting protein's smooth surface repelled all the drugs they threw at it. Amgen scientists identified and exploited a critical weakness: small, previously unrecognized pockets that allowed Lumakras to bind to the protein and flip the off switch, according to I-Fen Chang, vice president of oncology global development at Amgen, in an email. Despite the excitement surrounding its launch, Lumakras has seen modest commercial success, largely due to a limited patient population and reimbursement challenges, especially in markets outside the U.S., said Neha Anand, an analyst at Citeline. Th
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