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Bionano Announces Publication Showing OGM Can Overcome Key Limitations of Targeted RNA-Seq for Cytogenetic Investigation in Acute Leukemia

Bionano Genomics, Inc. (BNGO) 
Last bionano genomics, inc. earnings: 8/8 04:05 pm Check Earnings Report
Company Research Source: GlobeNewswire
SAN DIEGO, Nov. 06, 2025 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) today announced the publication of a study in Cancers from The University of Texas MD Anderson Cancer Center showing how optical genome mapping (OGM) can address key limitations of targeted RNA-sequencing (RNA-seq) panels in detecting therapeutically-relevant gene rearrangements in acute leukemias. This peer-reviewed publication, entitled “Comparative Analysis of Targeted RNA-Seq and Optical Genome Mapping for Detecting Gene Rearrangements in Acute Leukemia,” is the first to describe the comparison of OGM and RNA-seq in cancer. While RNA-seq panels are useful for detecting expressed variants, including chimeric transcripts, they have limitations. For example, when rearrangements lead to overexpression of a gene under a hijacked enhancer or when fusion transcripts are absent or poorly expressed, RNA-seq analysis may yield false-negative results. OGM complements RNA-seq with its ability to detect struc Show less Read more
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