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Candel Therapeutics reports extended survival in Phase 2a lung cancer trial of CAN-2409 [Yahoo! Finance]

Candel Therapeutics, Inc. (CADL) 
Company Research Source: Yahoo! Finance
Candel Therapeutics Inc (NASDAQ:CADL) has reported updated clinical data showing extended survival outcomes from its ongoing phase 2a trial of aglatimagene besadenovec (CAN-2409) in patients with advanced non-small cell lung cancer (NSCLC) who had previously shown an inadequate response to immune checkpoint inhibitors (ICIs). The additional 12 months of follow-up data indicate that 50% of the 46 patients in the per-protocol population remained alive at 24 months after treatment. Longer-term survival was also observed, with 35% of patients surviving beyond 30 months, 26% beyond 36 months, 24% beyond 40 months, and 13% exceeding 50 months. These figures represent an improvement compared to an earlier data cut, which showed 39% survival at 24 months. Median overall survival (mOS) reached 25.4 months among evaluable patients across cohorts 1 and 2. In a subgroup of patients with progressive disease despite prior ICI therapy, mOS was 21.5 months, while patients with non-squamous his Show less Read more
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