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Stock impact report

Targeted therapies to join chemo as oncology treatment backbone [Yahoo! Finance]

Candel Therapeutics, Inc. (CADL) 
Company Research Source: Yahoo! Finance
treatment towards the use of regimens incorporating targeted therapies. This trend has seen several new drugs become embedded into treatment paradigms across haematological cancers and solid tumours. This shift is, in part, driven by the cytotoxicity associated with chemotherapy, which can have a significant impact on a patient's quality of life (QoL), as well as their ability to tolerate further treatment if they were to relapse. In terms of sales and uptake of targeted therapies, immune checkpoint inhibitors (ICIs) are arguably one of the greatest success stories. This is evidenced by the broad use of MSD's Keytruda (pembrolizumab) across more than 40 cancer indications, as well as its 2025 sales of $31.7bn – making it one of the best-selling drugs currently on the market. Antibody-drug conjugates (ADCs), monoclonal antibodies (mAbs), kinase inhibitors, chimeric antigen receptor T-cell (CAR-T) therapies and radiopharmaceuticals are also making their mark on the space. More tar Show less Read more
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