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Stock impact report

CymaBay, GenKyoTex, And Intercept In PBC: The Clinical Differentiation [Seeking Alpha]

CymaBay Therapeutics Inc. (CBAY) 
Last cymabay therapeutics inc. earnings: 3/12 04:01 pm Check Earnings Report
US:NASDAQ Investor Relations: ir.cymabay.com
Company Research Source: Seeking Alpha
Summary Any man or institution that tries to rob me of my dignity will lose - Nelson Mandela Investment Thesis Ocaliva by Intercept ( ICPT ) was the first FDA approved therapy in twenty years for primary biliary cirrhosis (PBC). Currently, only two drugs, ursodeoxycholic acid (UDCA) and ocaliva, are FDA approved to therapeutically delay the progression of cirrhosis in PBC without improving pruritus (intense itching) and fatigue. PBC remains an incurable disease and the large number of drugs in clinical trials is expected to propel growth of the PBC drug market in future years. Many of the anti-cholestatic PBC drug candidates in clinical development are expected to mechanistically induce anti-cholestatic benefits mainly by suppressing bile acid synthesis in line with UDCA and ocaliva. Seladelpar by CymaBay ( CBAY ) is a PPAR-d agonist that is well positioned to be an improved second-line treatment for PBC relative to ocaliva. Seladelpar is currently in Phase 3 (pe Show less Read more
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