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Stock impact report

Addex stock tanks after lead drug flops in Phase II epilepsy trial [Yahoo! Finance]

Cerevel Therapeutics Holdings, Inc. (CERE) 
Company Research Source: Yahoo! Finance
Following the release of the Phase II top-line results, the Swiss company's stock was down by 53.3% at the market close on 29 April compared to the market close on the previous day. According to Yahoo Finance , Addex's market cap stands at $8.8m. The placebo-controlled Phase II trial (NCT04836559) evaluated ADX71149 (JNJ-40411813) as an adjunct therapy in 110 patients with epilepsy. The study failed to achieve statistical significance for the primary endpoint of time for patients to reach baseline seizure count. Addex did not provide additional information regarding the future of drug development. However, the company's chief medical officer, Roger Mills, added: “We will provide details on data from the full study when this analysis is completed and will work with our partner to determine the next steps for the ADX71149 program.” ADX71149 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor-2 (mGlu2 receptor), which plays a key role in seizure initiation Show less Read more
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